Used High-resolution tandem mass spectrometer
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- Capable of achieving a FWHM: over 40,000
- Accurate mass : <1 ppm RMS
- Acquisition speed: 30 mass spectra per second
Introduction
- Waters Synapt G2-S high-resolution mass spectrometer, which belongs to the quadrupole – ion mobility – time-of-flight tandem mass spectrometry (Q-IMS-TOF) equipment.
- Capable of achieving a FWHM of over 40,000.
- Accurate mass (<1 ppm RMS).
- Precise isotope abundance.
- The mass spectrometry dynamic range and the linear range of the detector response can reach up to 10^55.
- Acquisition speed up to 30 mass spectra per second.
- The high-resolution tandem mass spectrometer combining ion mobility spectrometry (IMS) and orthogonal accelerated time-of-flight (oa-TOF) technology, which achieves high sensitivity and wide dynamic range through StepWave technology, can provide high-quality numbers and high resolution, enabling precise separation and identification of complex mixtures in samples. It is particularly suitable for fields such as proteomics, metabolomics, and natural product analysis, and is renowned for its powerful separation ability and structural analysis capability.
Innovative features of the instrument
- Compared with previous models, the signal detection intensity of SYNAPT G2-S has increased by approximately 30 times, the signal-to-noise ratio has improved by 5-6 times, and the detection limit has been reduced by one order of magnitude.
- Selectivity and analytical capability: G2-S can perform qualitative and quantitative analysis of substances at concentrations lower than those of any other high-resolution mass spectrometers.
- SYNAPT G2-S equipped with a MALDI ion source can also conduct MALDI Imaging experiments. Compared with conventional MALDI Imaging techniques, through the use of T-Wave technology, scientists can obtain more abundant and reliable experimental data, and thus it has been widely applied.
Core application
The core application of the high-resolution tandem mass spectrometer is the precise qualitative, quantitative and structural analysis of target compounds in complex samples. With its high resolution, high accuracy and multi-level fragmentation capabilities, it is suitable for trace analysis and unknown substance identification in various fields.
Application fields
- Biomedicine and life sciences (analyzing plasma, serum, etc.)
- Pharmaceuticals and biopharmaceuticals (distinguishing isomeric impurities through high-resolution and ion mobility separation)
- Environmental and food testing (detecting water bodies, soil)
- In summary, Synapt G2-S is a top-level mass spectrometry platform that integrates sensitivity, resolution, and separation. Through multi-dimensional separation and precise mass analysis, it meets the most demanding analytical requirements for complex samples in life science research.
